Friday, July 12, 2024

What Is The New Shingles Shot

How Long After Ive Received The Shingles Vaccine Am I Contagious

New Shingles Vaccine

With the currently authorized shingles vaccine, Shingrix, you wont be contagious. The old vaccine, Zostavax, used a weakened form of the live varicella-zoster virus. Therefore, people worried about spreading the disease to the people around them.

Shingrix doesnt use a live version of the varicella-zoster virus. It is inactivated, which means it uses a dead version of the virus. Therefore, you have no risk of transmitting the disease to anyone.

A note from Cleveland Clinic

No one likes to get shots, especially for something youve already been vaccinated for. But the newer version of the shingles vaccine is one youll want to offer up your arm for. The Shingrix vaccine is more than 90% effective at helping you prevent shingles. Since most of us have had chickenpox in the past, the shingles vaccine is an easy way to prevent the dormant chickenpox virus from creeping up and hitting you again with shingles.

Know The Benefits And The Side Effects

Shingrix is more than 90% effective at preventing shingles and long-term nerve pain. You may experience some short-term side effects because Shingrix causes a strong response in your immune system.

After getting Shingrix:

  • Most people had a sore arm.
  • Many people had redness and swelling where they got the shot .
  • Many felt tired, had muscle pain, a headache, shivering, fever, stomach pain, or nausea.

About 1 out of 6 people who got Shingrix experienced side effects that prevented them from doing regular activities like yardwork or swimming. Side effects usually go away after 2 to 3 days. Remember that the pain from shingles can last a lifetime, and these side effects should only last a few days.

Should You Get The New Shingles Vaccine

One out of every three Americans will develop shingles in their lifetime. The painful, blistery skin rash that appears on the chest is caused by the same virus thats responsible for chickenpox. So, if youve ever had chickenpox, youre at risk for shingles, which can last from two to four weeks.

The first shingles vaccine, Zostavax, was approved in 2006 by the U.S. Food and Drug Administration , but a second newer drug is even more effective overall 90 percent versus 50 percent for Zostavax. Called Shingrix, the new vaccine became available in late 2017 and maintains its effectiveness in the age group most at-risk for developing the disease. For those age 70 or older, Shingrix is 91 percent effective.

A two-dose vaccine, Shingrix is administered eight weeks apart. The vaccine also contains an immune system booster and may reduce a form of chronic nerve pain commonly associated with shingles. A clinical trial showed that the vaccine maintains its effectiveness for up to four years.

The Centers for Disease Control and Preventions Advisory Committee on Immunization Practices recommends Shingrix for Americans 50 and older. However, not all health plans cover the vaccines cost, so check with your insurance provider first.

If youre under age 60 and unsure of whether youve had chickenpox or if you were previously vaccinated with Zostavax talk to your doctor about whether you should get the Shingrix vaccine.

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How Does The New Vaccine Work

Shingrix contains broken-down parts of the virus which then allow the body to build up immunity to the virus. When the body confronts the actual virus in the future, it mounts a response to keep the infection at bay. The vaccine also contains molecules that make the bodys immune response stronger and last longer.

For these reasons, Shingrix provides better and longer-lasting protection against both shingles and PHN than the older vaccine, Zostavax.

Protection from the older vaccine wore off after approximately eight years, but we believe Shingrix to last much longer.

When Should I See A Doctor Because Of The Side Effects I Experience From Shingrix

Expert panel recommends new shingles vaccine

Shingrix causes a strong response in your immune system, so it may produce short-term side effects. These side effects can be uncomfortable, but they are expected and usually go away on their own in 2 or 3 days. You may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen. Contact your healthcare provider if the symptoms are not improving or if they are getting worse.

In clinical trials, Shingrix was not associated with serious adverse events. In fact, serious side effects from vaccines are extremely rare. For example, for every 1 million doses of a vaccine given, only one or two people might have a severe allergic reaction. Signs of an allergic reaction happen within minutes or hours after vaccination and include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness. If you experience these or any other life-threatening symptoms, see a doctor right away.

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The Problem With Medical Records Tracking Vaccine Schedules

Another obstacle is the fact that it can be difficult for family physicians to know exactly what vaccinations a patient has received. Unlike pediatric patients, who typically have accessible records of their vaccination schedule, it can be trickier for adults.

For adults, it becomes quite challenging, especially when they switch providers, because often times you have to track down records to find out if theyve been vaccinated, said Jain.

She said it can be complicated to try and decipher which vaccines patients have received and which ones they should get without clear records.

For adults over the age of 65, you want to find out if theyve gotten the two pneumonia vaccinations that are recommended, so it becomes a challenge to find out if theyve gotten both, or just one, she said.

Same thing goes now for the shingles vaccination. Youre kind of tracking down records, and when you dont have them, you have to make a clinical judgment.

Despite these challenges, Jain says the fact that Shingrix is a newly minted vaccination may make things a bit more straightforward.

The nice thing about Shingrix is that its so new, most patients have not gotten it, she said. Even if theyve had Zostavax, its recommended that they get Shingrix in addition to it, so thats a little bit less of a challenge with a new vaccination.

Shingrix Use For Immunocompromised Adults

The CDC stated on Feb. 17, 2022: that the Shingrix vaccine is recommended for persons 19 years old and older who have altered immunocompetence. And vaccination of Contacts of Persons with Altered Immunocompetence Household contacts and other close contacts of persons with altered immunocompetence should receive all age- and exposure-appropriate vaccines, except for the smallpox vaccine.

During the U.S. CDC’s Advisory Committee on Immunization Practices meeting on October 20, 2021, Tara Anderson, DVM, MPH, Ph.D., presented: Interpretation of the EtR Regarding Use of RZV in Immunocompromised Adults, Considerations for Use, and Proposed Policy Options. The ACIP’s Recommendation is: Two doses of recombinant zoster vaccine are recommended for adults aged 19 years who are immunodeficient or immunosuppressed due to disease or therapy to prevent herpes zoster and its complications.

Previously, Camille Nelson Kotton, M.D., Chair, ACIP Herpes Zoster Work Group, presented the Introduction Zoster Vaccines Session on September 29, 2021 Ismael R. Ortega-Sanchez, Ph.D. presented ‘Economics of vaccinating immunocompromised 1949-years-old adults against herpes zoster in the USA Tara Anderson, DVM, MPH, Ph.D. presented ‘Preliminary Evidence to Recommendations Framework Regarding Use of Recombinant Zoster Vaccine in Immunocompromised Adults and Next Steps.’

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New More Effective Shingles Vaccine Offers Greater Protection

A vaccine against shingles has been available for several years, but a new vaccine promises to offer greater protection and significantly limit the suffering from shingles. Approved by the Food and Drug Administration last October, the Shingrix vaccine provides a 90 percent protection rate for older adults, compared with 50 percent for the previously available Zostavax vaccine. And unlike its predecessor, Shingrix can safely be given to those with compromised immune systems.Close to one-in-three Americans will develop shingles, a rash of itchy blisters similar but more painful than chicken pox. Usually appearing in a swath on the side of the face or torso, shingles feels, as one sufferer described it, like being pressed against a cactus.

The old vaccine is a live vaccine, says Daniel Z. Uslan, MD, an infectious diseases physician and director of the UCLA Antimicrobial Stewardship Program. It makes your body immune by exposing it to a live but weakened shingles virus. The new vaccine is an inactivated recombinant vaccine, meaning there is no live virus in it. Its a much safer vaccine that we can use in patients with weaker immune systems. And those are the people who need the vaccine because theyre most likely to get shingles and have complications from shingles.

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Shingrix Shingles Vaccine For 2022

Promising New Herpes Zoster Vaccine

GlaxoSmithKline plc Shingrix is a non-live, adjuvanted recombinant shingles vaccine consisting of the varicella-zoster virus glycoprotein E antigen and the AS01B adjuvant system, a proprietary adjuvant containing QS-21 and MPL with liposomes. Shingrix has been up to 90% effective in various clinical trials, says GSK. Shingrix has been commercially available since 2017.

Shingles, also known as herpes zoster , is a painful skin rash caused by reactivation of the varicella-zoster virus, which causes chickenpox, says the U.S. CDC. In addition, Shingrix works to boost human immune systems as people age, which increases the risk for shingles.

On February 25, 2021, U.S. CDC Advisory Committee on Immunization Practices Herpes Zoster Work Group presented the results of a comprehensive risk-benefit analysis of Shingrix that included a review of post-marketing data. The analysis of clinical trials, observational studies, and risk-benefit analysis confirm the considerable benefits of RZV vaccination in preventing HZ, severe disease, and complications. And the National Institute on Aging says ‘the shingles vaccine is safe and easy, and it may keep people from getting shingles and ongoing pain called postherpetic neuralgia.

London, England-based GlaxoSmithKline is the producer of Shingrix. GSK’s top priority is patient safety.

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Shingrix Vaccine Efficacy And Duration Of Protection

Among immunocompetent adults 50 years and older, the efficacy of two doses of Shingrix for the prevention of herpes zoster was high among all age groups. In a clinical trial of more than 30,000 participants, vaccine efficacy was 96.6% in adults aged 50 to 59 years, 97.4% in adults aged 60 to 69 years, and 91.3% in adults aged 70 years and older.

The efficacy of two doses of Shingrix for the prevention of postherpetic neuralgia was high: 91.2% in adults aged 50 years and older, and 88.8% in adults aged 70 years and older.

Vaccine efficacy was estimated among several immunocompromised groups:

  • 68.2% among adult autologous hematopoietic cell transplant recipients.
  • 87.2% in a post hoc efficacy analysis of adult patients with hematologic malignancies.
  • 90.5% in a post hoc efficacy analysis of adult patients with immune-mediated diseases who were not taking immunosuppressive medication.

In immunocompetent adults 70 years and older, vaccine efficacy remained high, at or above 84% in all 7 years after vaccination.

Shingles Vaccine And Insurance

Private health insurance plans often cover vaccination costs. Still, a patient might have a charge depending on the specific insurance plan.

Medicaid may or may not cover the vaccine cost.Medicare Part D plans cover the shingles vaccine, but there may be a cost to the patient depending on the plan. Usually, the fees are less than $50 per dose.

Medicare Part B does not cover the shingles vaccine.

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What Questions Should I Ask My Healthcare Provider

Its normal to have questions before you get a vaccine. Some common questions you may want to discuss with your healthcare provider include:

  • When should I get the shingles vaccine?
  • What side effects should I expect?
  • How does the shingles vaccine work?
  • When should I schedule each dose of the shingles vaccine?
  • How effective is the shingles vaccine?
  • Is there any reason I shouldnt get the shingles vaccine?
  • What could happen if I dont get the shingles vaccine?

Uncommon Rare And Very Rare Adverse Events

GSK Shingles Vaccine

Uncommon adverse events occur in 0.1% to less than 1% of vaccinees. Rare and very rare adverse events occur, respectively, in 0.01% to less than 0.1% and less than 0.01% of vaccinees.

Both HZ vaccines are safe with serious adverse events reported very rarely in immunocompetent individuals.

Recurrence or exacerbation of herpes zoster ophthalmicus following LZV vaccination has been reported very rarely, involving several cases world-wide following LZV immunization. Following a causality assessment of seven cases of HZO which were temporally associated with the administration of LZV, NACI concluded that there was insufficient evidence to recommend for or against the administration of LZV in individuals with a history of HZO. More evidence is required for further assessment of risk related to HZO recurrence in LZV recipients. At this time, there is insufficient evidence to assess the risk related to HZO recurrence following RZV recipients.

See Contraindications and Precautions if considering vaccinating a person with previous HZO.

For more information, refer to Adverse Events Following Immunization in Part 2 and the product monograph in Health Canada’s Drug Product Database.

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What Is The Brand Name Of The Shingles Vaccine

There are 2 shingles vaccines used in the UK:

  • Zostavax, a live vaccine given as 1 dose
  • Shingrix, a non-live vaccine given as 2 doses, 2 months apart

Most people will have the Zostavax vaccine. The Shingrix vaccine is recommended if Zostavax is not suitable for you, for example if you have a condition that affects your immune system.

You can read more about the shingles vaccines in the patient information leaflets:

What Can I Expect After Getting The Vaccine

Shingrix is a two-part vaccine with the second dose given 2-6 months after the first. If you miss this timeframe, then you do not have to repeat the series. The vaccine is given into the muscle, much like an influenza, pneumonia or tetanus vaccine.

Once you get the vaccine, you are more likely to experience fatigue, achy muscles, fever, shivering or upset stomach compared to the older vaccine. Approximately 11 percent of people who get the vaccine reported these flu-like symptoms and another nine percent reported mild pain, redness, and swelling at the site of the injection. These symptoms are more likely to occur after the second dose and typically resolve in a few days.

Shingrix represents a real opportunity to protect ourselves against a debilitating disease with remarkable and long-lasting effectiveness. Speak with your Methodist Physicians Clinic primary care provider about being vaccinated.

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Should You Get Shingrix If Youve Already Had The Zostavax Shot

Yes. The CDC recommends that you get the Shingrix vaccine if youve already had Zostavax, because its more effective than the older vaccine and the protection lasts longer. Wait at least 2 months after you have Zostavax to get Shingrix.

The committee will review the research, and it should offer more specific advice later this year.

Know Your Risk Of Getting Shingles And Complications

New shingles vaccine is 90 percent effective, doctors say

About 1 out of every 3 people in the United States will develop shingles during their lifetime.

If youve had chickenpox, you are at risk for shingles. More than 99% of Americans born before 1980 have had chickenpox, even if they dont remember it.

Your risk of getting shingles and having serious complications increases as you get older.

About 1 in 10 people who get shingles develop nerve pain that lasts for months or years after the rash goes away. This is called postherpetic neuralgia and is the most common complication of shingles.

Shingles may lead to other serious complications involving the eye, including blindness. Very rarely, it can also lead to pneumonia, hearing problems, brain inflammation or death.

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What Are The Benefits Of The Shingles Vaccine

The shingles vaccines are the best way to protect you from getting shingles. The vaccines have been shown to reduce the risk of getting shingles by 50% for Zostavax® II, and to more than 90% for Shingrix®.

For those who still get shingles after being immunized, the vaccines can reduce pain, including the type of pain that lasts after shingles.

Who Shouldn’t Get A Shingles Vaccine

The CDC says some people shouldn’t get the shingles vaccine. That includes those who:

  • Have ever had a severe allergic reaction to any component of the vaccine or after a dose of Shingrix
  • Tested negative for VZV immunity
  • Currently have shingles
  • Have a severe or moderate acute illness, such as a respiratory infection

Your healthcare provider can answer any questions you have about whether the vaccine is safe for you.

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Side Effects And Counseling For Reactogenicity

In eight clinical trials of more than 10,000 immunocompetent participants 50 years or older, grade 3 reactions were common after patients received Shingrix. About 1 out of 10 adults who received Shingrix reported grade 3 injection-site symptoms such as pain, redness, and swelling. Also, about 1 out of 10 reported grade 3 systemic reactions such as myalgia, fatigue, headache, shivering, fever, and gastrointestinal illness. Most people who got Shingrix reported at least some pain at the injection site.

Local and systemic grade 3 reactions among immunocompromised adults were evaluated in six studies in five immunocompromised groups. Local grade 3 reactions occurred in 10.7% to 14.2% of RZV recipients, and systemic grade 3 reactions occurred in 9.9% to 22.3% of RZV recipients, compared with 0% to 0.3% and 6.0% to 15.5%, respectively, among placebo recipients. The most commonly reported systemic symptoms were fatigue and myalgia.

Healthcare providers should counsel patients about expected reactogenicity before administering Shingrix.

What to tell patients about the side effects of Shingrix:

Most people have a sore arm after they get Shingrix. Many people have redness and swelling on their arm spanning several inches where they got the shot. Many people also feel tired or have muscle pain, a headache, shivering, fever, stomach pain, or nausea.

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