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When To Get The Second Shingles Shot

Live Shingles Vaccine Vs Non

Shingles: Signs, Symptoms and Treatment with Dr. Mark Shalauta | San Diego Health

A live vaccine is one that contains a weakened form of a germ. Shingrix is not a live vaccine. Its an inactive vaccine, which is a vaccine thats made from a germ thats been killed.

Because Shingrix is inactive, more people can receive it. This includes people with a weakened immune system .

Zostavax was a shingles vaccine that was live.

People with weakened immune systems are typically advised against receiving live vaccines. This is because on very rare occasions, live vaccines can mutate back to the full-strength germ that causes a disease. If this happens, people with weakened immune systems would have a much higher risk for developing the disease that the vaccine is meant to prevent.

What Is Shingles / Herpes Zoster

  • Shingles, also known as herpes zoster, is caused by the same virus as chickenpox. After chickenpox blisters heal, the herpes zoster virus stays, hiding in the bodys nerve cells.
  • The virus may be inactive for many years, but for unknown reasons, it can become active again and cause shingles. It can happen to anyone who has had chickenpox, but the risk increases as you get older, especially if you are over 50 years of age two thirds of shingles cases occur over the age of fifty.
  • Nearly one in three Canadians develops shingles during their lifetime.
  • Shingles causes a painful, blister-like rash that usually appears on one side of the body or face. Up to 4 days before the rash appears, there is often pain, itching or tingling at the site.
  • The blisters scab over in 3 to 5 days and can last for 2 to 4 weeks. You might also have a fever, chills, headache and upset stomach.
  • In addition to the pain from the rash, the underlying nerve pain caused by shingles has been described as burning, throbbing and/or stabbing. It can last for months or years.
  • People with shingles may have other complications, including scarring, bacterial skin infections, weakness, muscle paralysis and loss of hearing and/or vision.

Why Do I Need Two Doses Of Shingrix

In addition to a painful rash, shingles can lead to serious health complications like PHN, pneumonia, vision loss, hearing problems, and encephalitis . Research indicates that about 1% to 4% of people with shingles will be hospitalized.

Two doses of Shingrix offer effective protection against shingles and related complications for at least seven years. Among healthy adults ages 50-69, Shingrix is more than 90% effective in preventing PHN when two doses are administered. Among adults ages 70 and older, it is 89% effective.

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What Does The Shingles Vaccine Do

The shingles vaccine can prevent shingles. Every year, about 1 million people in the United States get shingles. Anyone whos had chickenpox can get shingles. Thats because the varicella-zoster virus lives silently in your nervous system after you’ve had chickenpox. The virus can reactivate later in your life if your immune system is weakened. Your risk of getting shingles goes up as you get older. In the United States, 1 in 3 people will get shingles in their lifetime.

Whos Most At Risk Of Shingles

Shingles and Shingrix

People tend to get shingles more often as they get older, especially over the age of 70. And the older you are, the worse it can be. The shingles rash can be extremely painful, such that sufferers cannot even bear the feeling of their clothes touching the affected skin.

The pain of shingles can also linger long after the rash has disappeared, even for many years. This lingering pain is called post-herpetic neuralgia .

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Are Shingrix And Zostavax The Same

Both Shingrix and Zostavax can decrease the risk of shingles. However, they differ in effectiveness, administration, and side effects. Shingrix is a recombinant zoster vaccine and Zostavax is a live vaccine. Meaning, Shingrix contains an inactivated form of the varicella-zoster virus and Zostavax contains a live, weakened form of the virus. Another difference is that Shingrix is injected into the muscle while Zostavax is injected underneath the skin. Compared to Zostavax, Shingrix is a newer shingles vaccine.

What If There Is A Serious Problem

An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction , call 9-1-1 and get the person to the nearest hospital.

For other signs that concern you, call your health care provider.

Adverse reactions should be reported to the Vaccine Adverse Event Reporting System . Your health care provider will usually file this report, or you can do it yourself. Visit the VAERS website at www.vaers.hhs.gov or call 1-800-822-7967. VAERS is only for reporting reactions, and VAERS staff members do not give medical advice.

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When Should I See A Doctor Because Of The Side Effects I Experience From Shingrix

Shingrix causes a strong response in your immune system, so it may produce short-term side effects. These side effects can be uncomfortable, but they are expected and usually go away on their own in 2 or 3 days. You may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen. Contact your healthcare provider if the symptoms are not improving or if they are getting worse.

In clinical trials, Shingrix was not associated with serious adverse events. In fact, serious side effects from vaccines are extremely rare. For example, for every 1 million doses of a vaccine given, only one or two people might have a severe allergic reaction. Signs of an allergic reaction happen within minutes or hours after vaccination and include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness. If you experience these or any other life-threatening symptoms, see a doctor right away.

Who Should Not Get The Shingles Vaccine

Shingles: What you need to know about causes, symptoms, and prevention.

Some people shouldnt get the shingles vaccine. These people include those:

  • Who currently have shingles.
  • Who have had a severe allergic reaction to the shingles vaccine in the past.
  • Who have tested negative for immunity to the varicella-zoster virus, meaning youve never had chickenpox. If youve never had chickenpox, you should get the chickenpox vaccine.
  • Who are ill. You should wait until your illness has passed before receiving the shingles vaccine.
  • Who are pregnant or breastfeeding.

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Persons With No Documented History Of Varicella Varicella Vaccination Or Herpes Zoster

Shingles is caused by VZV . After a person recovers from varicella, the virus stays dormant in their body. The virus can reactivate years or decades later, causing shingles.

  • Persons who have neither experienced varicella nor received varicella vaccine are not at risk for shingles.
  • More than 99% of Americans born before 1980 have had varicella, even if they dont remember it .
  • Children and adolescents who have received live-attenuated varicella vaccines are at lower risk for shingles than are those who experienced varicella .

RZV is not indicated and has not been studied for the prevention of varicella.

  • Receipt of RZV is not considered proof of prior varicella disease or varicella immunity.
  • RZV cannot be considered as either of the two doses of the varicella vaccine series.

For immunocompromised persons, evidence of immunity to varicella includes:

  • Documentation of two doses of varicella vaccine, or
  • Laboratory evidence of immunity or laboratory confirmation of disease, or
  • Diagnosis or verification of a history of varicella or herpes zoster by a healthcare provider.

It is important to note that:

For immunocompromised adults with no documented history of varicella, varicella vaccination, or shingles:

What Are The Risk Factors For Recurring Shingles

People dont know what causes recurring shingles, but certain factors increase your chances of getting shingles again.

People with weakened immune systems are more likely to get shingles again. One study determined that the rate of shingles recurrence was among people with compromised immune systems. This is about 2.4 times higher than for those who didnt have compromised immune systems.

You may have a compromised immune system if you:

  • are getting chemotherapy or radiation therapy
  • have organ transplants
  • are taking high doses of corticosteroids like prednisone

Additional risk factors include:

  • longer-lasting and more severe pain with the first case of shingles
  • pain for 30 days or more with the first case of shingles
  • being over the age of 50

Having one or more blood relatives with shingles may also increase your risk of getting shingles.

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Reporting Of Vaccine Adverse Events

Adverse events that occur in a patient following vaccination can be reported to the Vaccine Adverse Events Reporting System . Reporting is encouraged for any clinically significant adverse event even if it is uncertain whether the vaccine caused the event. Information on how to submit a report to VAERS is available at or by telephone at 1-800-822-7967.

* This recommendation became official CDC policy in January 2018.

Zoster vaccine live is no longer available for use in the United States, as of November 18, 2020.

§Grade 3 reactions are defined as reactions related to vaccination severe enough to prevent normal activities.

Why Is Shingrix Administered In Two Doses

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Shingrix is typically given in two doses, usually as a shot to the upper arm.

A 2021 study found that adults over 65 were significantly less likely to develop either shingles or PHN after getting two doses of Shingrix than they were after one dose. Two doses of Shingrix also offered better protection against shingles complications to adults over 80 and immunocompromised adults.

Previously, Zostavax was offered to older and immunocompromised adults to prevent shingles, PHN, and other shingles-related health problems. Zostavax is a live vaccine, which means it contains a weakened version of the herpes zoster virus. Shingrix is a recombinant vaccine, meaning that it uses only a small piece of the virus.

In 2017, the Food and Drug Administration approved Shingrix for the prevention of shingles and related complications. Zostavax is no longer available in the U.S. People who have gotten Zostavax in the past should now get Shingrix.

Studies have shown that Zostavaxa one-dose vaccineis generally less effective than two doses of Shingrix in preventing shingles complications among older and immunocompromised adults. Shingrix currently offers the best chance of protection against shingles, PHN, and shingles-related hospitalization.

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Conditions Treated By Shingrix And Zostavax

Shingrix and Zostavax are FDA approved to prevent shingles . Both vaccines are indicated to prevent shingles in adults aged 50 years and older. Shingrix and Zostavax are not used to prevent primary varicella infection, also known as chickenpox.

Postherpetic neuralgia is a common type of nerve pain that arises with shingles. Because Shingrix and Zostavax can prevent shingles, they can also prevent postherpetic neuralgia and other painful complications from shingles. However, these vaccines are not labeled to treat PHN.

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When Should You Get Immunised Against Shingles

Anyone aged 60 years and over who wants to protect themselves against shingles can talk to their doctor about getting immunised.

Shingles immunisation is recommended for:

  • adults aged 60 years and over who have not previously received zoster vaccine
  • adults aged 70 years to 79 years, for free under the National Immunisation Program
  • adults aged 50 or over who live in the same household as someone who has a weakened immune system.

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Shingrix For Prevention Of Shingles

Shingrix is a vaccine thats used to prevent shingles . Its approved for use in people:

  • ages 50 years and older
  • ages 18 years and older who have an increased risk of shingles

People with an increased risk of shingles include those with a weakened immune system, such as people with HIV.

Shingrix is not meant for use in preventing chickenpox .

Effectiveness for prevention of shingles

Shingrix has been found to be effective in helping to prevent shingles. For details on how the drug performed in clinical studies, see Shingrixs

state that Shingrix is the preferred vaccine for shingles. They recommend it for:

  • all adults ages 50 years and older
  • adults ages 18 to 50 years with a weakened immune system

Is Shingrix Or Zostavax Better

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Shingrix is more effective than Zostavax. Shingrix is 97% effective at preventing shingles in adults aged 50 to 69 years old whereas Zostavax is only 70% effective at preventing shingles in the same age group. Shingrix consistently prevents shingles in older adults while the effectiveness of Zostavax decreases with increasing age. However, Shingrix has more systemic side effects than Zostavax.

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If Youre 50 Or Older Get Shingrix

  • Shingrix provides strong protection from shingles and long-term nerve pain.
  • Get Shingrix even if you already had shingles, because you can get the disease more than once.
  • Your risk of shingles and complications increases as you age.
  • You need 2 doses of Shingrix. Get the second dose 2 to 6 months after you get the first dose.

How Does The Shingles Vaccine Work

The vaccine recommended for most people is a live vaccine called Zostavax. It contains a weakened chickenpox virus . Its similar, but not identical, to the chickenpox vaccine.

People with a weakened immune system cannot have live vaccines. They will be offered a non-live vaccine called Shingrix. It activates the immune system but also contains an ingredient called an adjuvant, which helps to boost the response to the vaccine.

Very occasionally, people develop chickenpox following shingles vaccination . Talk to a GP if this happens to you.

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Know Your Risk Of Getting Shingles And Complications

About 1 out of every 3 people in the United States will develop shingles during their lifetime.

If youve had chickenpox, you are at risk for shingles. More than 99% of Americans born before 1980 have had chickenpox, even if they dont remember it.

Your risk of getting shingles and having serious complications increases as you get older.

About 1 in 10 people who get shingles develop nerve pain that lasts for months or years after the rash goes away. This is called postherpetic neuralgia and is the most common complication of shingles.

Shingles may lead to other serious complications involving the eye, including blindness. Very rarely, it can also lead to pneumonia, hearing problems, brain inflammation or death.

How Is Shingles Spread

Private Shingles Vaccination With New Non

You do not catch shingles it comes on when theres a reawakening of chickenpox virus thats already in your body. The virus can be reactivated because of a range of issues, including advancing age, medicine, illness or stress.

Anyone who has had chickenpox can get shingles. Its estimated that around 1 in 5 people who have had chickenpox go on to develop shingles.

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What Are The Symptoms Of Shingles

Shingles is a painful rash that develops on one side of the face or body. The rash forms blisters that typically scab over in 7-10 days. Shingles typically takes 2-4 weeks to clear up.

People often feel pain, itching, or tingling in the area 1-5 days before the rash appears.

Most commonly, shingles forms a single stripe of rash on either the left or right hemisphere of the body. Occasionally, the rash occurs on one side of the face. Less commonly, the rash looks similar to chickenpox and is spread more liberally . Shingles can sometimes affect the eyes and cause loss of vision.

Other symptoms of shingles can include fever, headache, chills and upset stomach.

Administration With Other Vaccines

CDC general recommendations advise that recombinant and adjuvanted vaccines, such as Shingrix, can be administered concomitantly, at different anatomic sites, with other adult vaccines, including COVID-19 vaccines. Concomitant administration of Shingrix with Fluarix Quadrivalent , 23-valent pneumococcal polysaccharide vaccine and Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed , and 13-valent pneumococcal conjugate vaccine has been studied, and there was no evidence for interference in the immune response to either vaccine or safety concerns. Coadministration of Shingrix with adjuvanted influenza vaccine and COVID-19 vaccines is being studied.

Shingrix and pneumococcal vaccine can be administered at the same visit if the person is eligible for both. When both pneumococcal conjugate vaccine PCV13 and PPSV23 are recommended for an adult, PCV13 should always be administered first and can be administered concomitantly with Shingrix.

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Is There Any Reason I Shouldnt Get It

Only if you have a compromised immune system.

Show Sources

News release, FDA. William Schaffner, MD, president, National Foundation for Infectious Diseases professor, chairman, department of preventive medicine professor of medicine, division of infectious diseases, Vanderbilt University School of Medicine.

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Who Should Not Have The Shingles Vaccine

How Can You Prevent Shingles

You should not have the shingles vaccine if you’ve had a serious allergic reaction in the past to a previous dose of the shingles vaccine, or to any of the ingredients in the vaccine, or to a previous dose of varicella vaccine.

If you have a weakened immune system a GP or practice nurse will assess which vaccine is suitable for you. Discuss any health concerns with the GP or practice nurse before you have the vaccine.

Zostavax is not suitable for people who have a weakened immune system due to a condition, treatment or medicine.

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Cdc Recommendation For The Shingles Vaccine

The Centers for Disease Control and Prevention recommend Shingrix as the preferred vaccine to prevent shingles and other complications from the disease.

The CDC found that Shingrix was more effective than Zostavax. It recommends that you receive Shingrix, even if youve had Zostavax in the past.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

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