No Link Found Between Shingles And Covid Vaccine In Larger Study
The findings of a trial involving more than 2 million people in the U.S. disputed smaller studies that reported a possible connection. Separately, more research is urged on the covid vaccine’s impact on menstrual cycles.
MedPage Today:Large U.S. Study Finds No Link Between COVID Vaccine And Shingles No association was detected between COVID-19 vaccination and herpes zoster infection in a database study involving more than 2 million individuals in the U.S. … Shingles following COVID-19 vaccination became a worry after some previous studies reported an elevated risk.
NBC News:Vaccine Trials Should Monitor Menstrual Changes, Researchers SayAlthough they made up around half the participants in Covid vaccine trials, women were not asked about any menstrual changes as part of that process. Since then, several studies have revealed that Covid vaccines can indeed induce short-term changes in menstrual cycles.
CIDRAP:Study: Severe COVID Less Likely In Kids Of Vaccinated Parents “The association between parent vaccination and reduced risk of admission for SARS-CoV-2 in children younger than 5 years suggests that parents played a major role in transmitting SARS-CoV-2 to their young children during both waves, but the association between protection and vaccination seemed lower in the Omicron vs Delta period,” the study authors wrote. “The Omicron variant has been shown to be more transmissible, and the vaccine effectiveness against infection seems lower.”
Shingrix Shingles Vaccine For 2022
GlaxoSmithKline plc Shingrix is a non-live, adjuvanted recombinant shingles vaccine consisting of the varicella-zoster virus glycoprotein E antigen and the AS01B adjuvant system, a proprietary adjuvant containing QS-21 and MPL with liposomes. Shingrix has been up to 90% effective in various clinical trials, says GSK. Shingrix has been commercially available since 2017.
Shingles, also known as herpes zoster , is a painful skin rash caused by reactivation of the varicella-zoster virus, which causes chickenpox, says the U.S. CDC. In addition, Shingrix works to boost human immune systems as people age, which increases the risk for shingles.
On February 25, 2021, U.S. CDC Advisory Committee on Immunization Practices Herpes Zoster Work Group presented the results of a comprehensive risk-benefit analysis of Shingrix that included a review of post-marketing data. The analysis of clinical trials, observational studies, and risk-benefit analysis confirm the considerable benefits of RZV vaccination in preventing HZ, severe disease, and complications. And the National Institute on Aging says ‘the shingles vaccine is safe and easy, and it may keep people from getting shingles and ongoing pain called postherpetic neuralgia.
London, England-based GlaxoSmithKline is the producer of Shingrix. GSK’s top priority is patient safety.
Moderna Announces 3 New Mrna Vaccine Targets Including Herpes And Cancer
Building on the momentum of its extraordinarily successful mRNA COVID-19 vaccine, biotechnology company Moderna has announced three new mRNA development targets. The company is now setting its vaccine sights on the herpes simplex virus, the varicella-zoster virus, and a novel cancer vaccine.
In early 2020, as the novel coronavirus SARS-CoV-2 swiftly spread across the world triggering a global pandemic, mRNA vaccine researchers kicked into gear. Decades of work had luckily positioned this new technology as ready for a move into the big time and by the end of the year mRNA COVID-19 vaccines were demonstrating extraordinary safety and efficacy.
The acceleration of mRNA vaccines from experimental technology to the arms of billions of people paved the way for new research avenues. So while it is clear the technology can make for a safe and effective COVID-19 vaccine, what else can it do?
Moderna, one of the biotech companies leading the mRNA pack, has just announced a trio of new developmental targets. These three new mRNA vaccine targets sit alongside the companys previously announced focuses on HIV, influenza, cytomegalovirus , and the Epstein-Barr virus .
The biggest newly announced target is a mRNA vaccine against the herpes simplex virus . There are two types of herpes virus HSV-1, the virus known to affect the mouth and cause cold sores, and HSV-2, more commonly the source of genital herpes.
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Warnings Of Shingrix And Zostavax
Shingrix and Zostavax can cause hypersensitivity, or allergic, reactions in those with allergies to vaccine ingredients. Zostavax may cause severe allergic reactions in those with a known allergy to gelatin or neomycin. Severe allergic reactions can lead to severe rash and trouble breathing .
Zostavax should be avoided in those who take immunosuppressive agents and those who are affected by medical conditions that weaken the immune system.
Ask your doctor or pharmacist about other precautions before getting a shingles vaccine.
Drug Interactions Of Shingrix Vs Zostavax
Immunosuppressive drugs such as cyclosporine and tacrolimus can decrease the effectiveness of vaccines. Steroids, like prednisone, and chemotherapy can also have immunosuppressive effects that can alter how vaccines work.
Those who are on immunosuppressive therapy should avoid Zostavax altogether Zostavax contains the live virus, which could result in an infection.
Antiviral drugs such as acyclovir and famciclovir can interfere with the effects of the Zostavax vaccine. The Advisory Committee on Immunization Practices recommends that people who are on antiviral drugs stop taking antiviral medications 24 hours before getting a Zostavax vaccine. Treatment with antiviral drugs should not be resumed for at least 14 days after vaccination with Zostavax.
Consult a healthcare professional for other possible drug interactions
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Who Should Not Get Shingrix
You should not get Shingrix if you:
- Have ever had a severe allergic reaction to any component of the vaccine or after a dose of Shingrix.
- Currently have shingles.
- Currently are pregnant. Women who are pregnant should wait to get Shingrix.
If you have a minor illness, such as a cold, you may get Shingrix. But if you have a moderate or severe illness, with or without fever, you should usually wait until you recover before getting the vaccine.
What Are The Possible Side Effects Of Shingrix
Studies show that Shingrix is safe. The vaccine helps your body create a strong defense against shingles. As a result, you are likely to have temporary side effects from getting the shots. The side effects might affect your ability to do normal daily activities for 2 to 3 days.
Most people got a sore arm with mild or moderate pain after getting Shingrix, and some also had redness and swelling where they got the shot. Some people felt tired, had muscle pain, a headache, shivering, fever, stomach pain, or nausea. Some people who got Shingrix experienced side effects that prevented them from doing regular activities. Symptoms went away on their own in about 2 to 3 days. Side effects were more common in younger people.
You might have a reaction to the first or second dose of Shingrix, or both doses. If you experience side effects, you may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen.
Guillain-Barré syndrome , a serious nervous system disorder, has been reported very rarely after Shingrix. There is also a very small increased risk of GBS after having shingles.
If you experience side effects from Shingrix, you should report them to the Vaccine Adverse Event Reporting System . Your doctor might file this report, or you can do it yourself through the VAERS websiteexternal icon, or by calling 1-800-822-7967.
If you have any questions about side effects from Shingrix, talk with your doctor.
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Is Shingrix Or Zostavax Better
Shingrix is more effective than Zostavax. Shingrix is 97% effective at preventing shingles in adults aged 50 to 69 years old whereas Zostavax is only 70% effective at preventing shingles in the same age group. Shingrix consistently prevents shingles in older adults while the effectiveness of Zostavax decreases with increasing age. However, Shingrix has more systemic side effects than Zostavax.
Shingrix Use For Immunocompromised Adults
The CDC stated on Feb. 17, 2022: that the Shingrix vaccine is recommended for persons 19 years old and older who have altered immunocompetence. And vaccination of Contacts of Persons with Altered Immunocompetence Household contacts and other close contacts of persons with altered immunocompetence should receive all age- and exposure-appropriate vaccines, except for the smallpox vaccine.
During the U.S. CDC’s Advisory Committee on Immunization Practices meeting on October 20, 2021, Tara Anderson, DVM, MPH, Ph.D., presented: Interpretation of the EtR Regarding Use of RZV in Immunocompromised Adults, Considerations for Use, and Proposed Policy Options. The ACIP’s Recommendation is: Two doses of recombinant zoster vaccine are recommended for adults aged 19 years who are immunodeficient or immunosuppressed due to disease or therapy to prevent herpes zoster and its complications.
Previously, Camille Nelson Kotton, M.D., Chair, ACIP Herpes Zoster Work Group, presented the Introduction Zoster Vaccines Session on September 29, 2021 Ismael R. Ortega-Sanchez, Ph.D. presented ‘Economics of vaccinating immunocompromised 1949-years-old adults against herpes zoster in the USA Tara Anderson, DVM, MPH, Ph.D. presented ‘Preliminary Evidence to Recommendations Framework Regarding Use of Recombinant Zoster Vaccine in Immunocompromised Adults and Next Steps.’
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Is Shingrix Or Zostavax More Effective
Shingrix and Zostavax have both been proven to prevent shingles. However, Shingrix is a newer vaccine that is considered more effective than Zostavax. Shingrix is even recommended for those who have already received the Zostavax vaccine in the past.
Clinical trials have shown that Shingrix is 97% effective at preventing shingles in adults aged 50 to 69 years old. Shingrix is also effective in preventing shingles in older adultsadults over the age of 70, Shingrix is 91% effective.
Zostavax has a 70% efficacy rate in preventing shingles in adults aged 50 to 69 years old, according to the Zoster Efficacy and Safety Trial . Results from the Shingles Prevention Study showed that Zostavax is 51% effective against shingles. Compared to Shingrix, the effectiveness of Zostavax decreases in older age groups. Based on the SPS results, Zostavax is 64% effective in adults aged 60 to 69 years old 41% effective in adults aged 70 to 79 years old and 18% effective in adults aged 80 years and older.
Your healthcare provider will most likely recommend Shingrix over Zostavax. Shingrix is especially recommended for immunocompromised patients since it is a non-live vaccine. Ask your doctor or pharmacist about which shingles vaccine is right for you.
Shingrix Vs Zostavax: How Do Various Shingles Vaccines Stack Up
Its important to understand what shingles is. Shingles is essentially a reactivation of chickenpox. Chickenpox is a bit of a misnomer. The pox ending refers to its blistering rash. For much of human history it was thought to be similar to smallpox . However, the two infections are entirely unrelated.
Why it was called chicken-pox is not entirely clear since the disease has nothing to do with chickens. A few theories have been put forward. One is that chicken-pox is a linguistic corruption of child-pox since the disease generally affects children. But the real reason is likely lost to history. In any case, we are better off referring to chickenpox by its scientific name of varicella.
Varicella is caused by the aptly named Varicella-zoster virus . Varicella is not a benign illness and it can be fatal, but most people survive the initial infection. However, even though the characteristic rash eventually disappears, the virus is never entirely cleared from the human body. It remains dormant in the dorsal root ganglia, a cluster of nerve cells that run parallel to the spine. Your immune system normally keeps the virus in check. But as we age, immunity can wane. By age 55, 30-40% of people have lost the specific immunity they had to the varicella-zoster virus and the virus can re-awaken.
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No Increased Risk Of Shingles After Covid
While the study above noted that there may be an increased risk of getting shingles after receiving a COVID-19 vaccine, a 2021 study had conflicting findings.
This study compared shingles onset within a 28-day period after either receiving an mRNA vaccine or getting a diagnosis for another skin condition. The people in the second group had no known history of receiving a COVID-19 vaccine.
The researchers matched these two groups of individuals 1-to-1 based on factors like age, sex, race or ethnicity, and health history. After this matching, they observed no increased risk of shingles between the two groups.
noted that most cases of shingles happen 1 to 2 weeks after having COVID-19 and have a typical presentation.
Older individuals may be more likely to develop shingles after having COVID-19. In a another 2022 study , researchers examined shingles in people who had experienced COVID-19 and people who had not. All people in the study were ages 50 and older.
Compared with people who hadnt had COVID-19, those that had experienced it had a 15% higher chance of shingles. This chance increased to 21% for individuals who experienced hospitalization for COVID-19.
Similar to getting shingles after a COVID-19 vaccine, the reason why COVID-19 can lead to shingles is unclear. It may happen due to immune dysfunction that occurs from COVID-19.
Pfizer And Biontech To Make Mrna
Pfizer PFE and its partner for COVID-19 vaccine BioNTech BNTX signed a new collaboration to develop an mRNA-based vaccine for the prevention of shingles, a painful and disfiguring disease.
Clinical studies on the mRNA-based shingles vaccine are expected to begin in the second half of 2022. The companies will make the vaccine by leveraging Pfizers antigen technology and BioNTech’s proprietary mRNA platform technology, which has been used to make their successful COVID-19 vaccine.
For the deal, Pfizer will make an upfront payment of $225 million to BioNTech that will include an upfront cash payment of $75 million and an equity investment of $150 million. In addition, BioNTech will also be entitled to receive potential milestone payments of up to $200 million while being eligible for a future share of gross profits, if some products are successfully developed.
This is Pfizer and BioNTechs third mRNA vaccine collaboration. Pfizer and BioNTech have successfully developed an mRNA-based vaccine for COVID-19, under a collaboration initiated in 2020, that is now authorized in several countries and is probably the most successful of all vaccines available. The COVID-19 vaccine has generated billions in revenues for companies. Pfizer and BioNTech also have a collaboration to make an mRNA-based influenza vaccine, which was initiated in 2018.
Pfizers stock has risen 56% in the past year compared with an increase of 22.1% for the industry.
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Are Shingrix And Zostavax The Same
Both Shingrix and Zostavax can decrease the risk of shingles. However, they differ in effectiveness, administration, and side effects. Shingrix is a recombinant zoster vaccine and Zostavax is a live vaccine. Meaning, Shingrix contains an inactivated form of the varicella-zoster virus and Zostavax contains a live, weakened form of the virus. Another difference is that Shingrix is injected into the muscle while Zostavax is injected underneath the skin. Compared to Zostavax, Shingrix is a newer shingles vaccine.
When Should I See A Doctor Because Of The Side Effects I Experience From Shingrix
Shingrix causes a strong response in your immune system, so it may produce short-term side effects. These side effects can be uncomfortable, but they are expected and usually go away on their own in 2 or 3 days. You may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen. Contact your healthcare provider if the symptoms are not improving or if they are getting worse.
In clinical trials, Shingrix was not associated with serious adverse events. In fact, serious side effects from vaccines are extremely rare. For example, for every 1 million doses of a vaccine given, only one or two people might have a severe allergic reaction. Signs of an allergic reaction happen within minutes or hours after vaccination and include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness. If you experience these or any other life-threatening symptoms, see a doctor right away.
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Can I Get Shingles If Ive Never Had Chickenpox
No, you cannot get shingles if youve never had chickenpox. Shingles is a reactivation of VZV, the virus that causes chickenpox. To get shingles, you must have had chickenpox or the chickenpox vaccine.
Chickenpox can be serious in adults. If you havent had chickenpox or the chickenpox vaccine, experts suggest that getting a vaccine against chickenpox can help prevent the chickenpox infection.
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We are absolutely thrilled to get to this point because the science behind this vaccine offers tremendous potential for helping patients, protecting them against getting shingles and its complications, said Dr. Leonard Friedland, vice president for scientific affairs and public health for GSKs North American vaccines unit.
Shingles is a delayed complication of chickenpox, a highly infectious disease most children suffered through in the era before the chickenpox vaccine was developed.
People who have had chickenpox harbor the varicella zoster virus the bug that causes the disease in their bodies after infection.
Healthy immune systems keep the virus in a dormant state. But people who have weakened immune systems, either because of an illness or because the immune system declines with age, can develop shingles.
The condition typically manifests as a painful, itchy rash, either on one side of the torso or one side of the face. The blisters can lead to ulcers and scars.
Theres nothing good about shingles, said Dr. Anne Louise Oaklander, a shingles expert who is director of the nerve unit at Massachusetts General Hospital.
And it can be quite bad. In the worst cases, people may not be able to put their clothing on. And it can leave ulcers and scars.
Shingles can also lead to strokes, vision and hearing loss, and other complications, Oaklander said.
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