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How Effective Is One Dose Of Shingles Vaccine

What Happens If You Dont Get A Second Shingrix Shot

What You Should Know About Shingles Vaccines | Johns Hopkins Medicine

The second Shingrix shot is important to ensure complete protection with the vaccine. Skipping the second dose of Shingrix may lead to reduced protection from shingles. However, you dont need to worry if more than six months have passed before you receive the booster shot. Just make sure you receive the second shot as close to the two- to six-month timeframe as possible.

Why You Probably Wont Need A Shingles Booster

Poland and Schaffner both noted that since the effectiveness of Shingrix seems to be lasting, its not likely that people will ever need a shingles booster shot after they receive their primary series, given as two shots six months apart.

At the moment, the recommendation is for everyone aged 50 and older to get this vaccine, said Schaffner. And after youve had your first two dosesso farthere does not appear to be a need for a follow-up.

Poland said that researchers will keep collecting data, as we always do and if there is ever evidence that the vaccine has lost effectiveness, we would know in time to either recommend a booster dosewhich I dont think its going to be likelyor do something else.

Alison Hunt, a spokesperson for GSK, the manufacturer of Shingrix, told Verywell that the company is committed to studying the longer-term efficacy, immunogenicity, and safety of the vaccine which was licensed in 2017.

The Zoster-049 study is still ongoing with final data expected in 2024. Upon study completion, the product information may be updated as appropriate, Hunt said.

Does Shingrix Require Two Shots

Shingrix is approved as a two-dose vaccine. It is not recommended to skip the second dose of Shingrix. Typically, the second Shingrix dose is administered two to six months after the first dose in adults aged 50 years and older. However, in people who are immunocompromised, the second dose can be given one to two months after the first dose.

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Know The Benefits And The Side Effects

Shingrix is more than 90% effective at preventing shingles and long-term nerve pain. You may experience some short-term side effects because Shingrix causes a strong response in your immune system.

After getting Shingrix:

  • Most people had a sore arm.
  • Many people had redness and swelling where they got the shot .
  • Many felt tired, had muscle pain, a headache, shivering, fever, stomach pain, or nausea.

About 1 out of 6 people who got Shingrix experienced side effects that prevented them from doing regular activities like yardwork or swimming. Side effects usually go away after 2 to 3 days. Remember that the pain from shingles can last a lifetime, and these side effects should only last a few days.

Mild Side Effects Of Shingles Vaccine:

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  • Redness, soreness, swelling, or itching at the site of the injection .

It is safe to be around infants and young children, pregnant women, or people with weakened immune systems after you get the shingles vaccine. There is no documentation of a person getting chickenpox from someone who has received the shingles vaccine .

Some people who get the shingles vaccine will develop a chickenpox-like rash near the place where they were vaccinated. As a precaution, this rash should be covered until it disappears.

Like all vaccines, shingles vaccine is being closely monitored for unusual or severe problems by CDC and FDA.

Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. These would start a few minutes to a few hours after the vaccination. If you have a severe allergic reaction or other emergency that cant wait, call 9-1-1 or get the person to the nearest hospital. Otherwise, call your doctor.

Afterward, the reaction should be reported to the Vaccine Adverse Event Reporting System . Your doctor might file this report, or you can do it yourself through the VAERS website, or by calling 1-800-822-7967.

The shingles vaccine does not contain thimerosal .

This information was taken directly from the Shingles Vaccine Information Statement dated 10/06/2009.

For more information on possible side effects from vaccination, visit CDCs Possible Side Effects from Vaccines page.

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Reasons To Get The Shingles Vaccine

Once a person develops chickenpox after contracting the varicella-zoster virus, the virus never leaves the body. It remains dormant in the nerve roots and can reappear as shingles later in life.

The primary symptom of shingles is a painful rash on one side of the body, most often on the torso or face. People initially have pain or a burning sensation on the skin without a rash, and then painful blisters develop. The rash lasts approximately seven to 10 days and fully clears within two to four weeks.

The likelihood of developing shingles increases dramatically after age 50. Therefore, the Centers for Disease Control and Prevention recommends that all adults age 50 and over receive two doses of Shingrix to prevent shingles. The vaccine is recommended even if a person is unsure if they have ever had chickenpox.

People with weakened immune systems are at higher risk for shingles. Therefore, the Food and Drug Administration also recently approved Shingrix vaccination for adults age 18 and older who are at risk for shingles due to immunodeficiency or immunosuppression caused by an underlying disease or medication.

Is Shingrix Or Zostavax Better

Shingrix is more effective than Zostavax. Shingrix is 97% effective at preventing shingles in adults aged 50 to 69 years old, whereas Zostavax is only 70% effective at preventing shingles in the same age group. Shingrix consistently prevents shingles in older adults, while the effectiveness of Zostavax decreases with increasing age. However, Shingrix may cause more systemic side effects than Zostavax.

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Study Population And Inclusion Criteria

To be included in the study, beneficiaries met the following criteria: alive and aged 65 years on the index date continuously enrolled in Medicare Part D for at least 12 months prior to the index date continuously enrolled in Medicare Parts A and B and not Part C for at least 15 months prior to the index date not in a nursing home, skilled nursing facility, or hospice on the index date and did not have a HZ diagnosis in the inpatient, institutional outpatient , or professional settings in the 1 year prior to the index date. To address concerns regarding potential confounding because of differences in prevention and healthy lifestyle, we further duplicated all analyses restricted to beneficiaries who had received an influenza vaccine between the start of the 20162017 influenza season and the index date.

Beneficiaries were classified into an autoimmune population if they consulted for any of the selected autoimmune conditions included at least twice in the 1 year prior to the index date. We adapted our autoimmune conditions definition from Cooper et al. 2009 , along with supporting literature .

If Youre 50 Or Older Get Shingrix

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  • Shingrix provides strong protection from shingles and long-term nerve pain.
  • Get Shingrix even if you already had shingles, because you can get the disease more than once.
  • Your risk of shingles and complications increases as you age.
  • You need 2 doses of Shingrix. Get the second dose 2 to 6 months after you get the first dose.

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When Should I See A Doctor Because Of The Side Effects I Experience From Shingrix

Shingrix causes a strong response in your immune system, so it may produce short-term side effects. These side effects can be uncomfortable, but they are expected and usually go away on their own in 2 or 3 days. You may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen. Contact your healthcare provider if the symptoms are not improving or if they are getting worse.

In clinical trials, Shingrix was not associated with serious adverse events. In fact, serious side effects from vaccines are extremely rare. For example, for every 1 million doses of a vaccine given, only one or two people might have a severe allergic reaction. Signs of an allergic reaction happen within minutes or hours after vaccination and include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness. If you experience these or any other life-threatening symptoms, see a doctor right away.

Contraindications And Precautions For Shingles Vaccination

Zostavax should not be administered to:

  • A person who has ever had a life-threatening or severe allergic reaction to gelatin, the antibiotic neomycin, or any other component of herpes zoster vaccine.
  • A person who has a weakened immune system because of:
  • HIV/AIDS or another disease that affects the immune system,
  • treatment with drugs that affect the immune system, such as steroids,
  • cancer treatment such as radiation or chemotherapy, or
  • cancer affecting the bone marrow or lymphatic system, such as leukemia or lymphoma.
  • Women who are or might be pregnant. Women should not become pregnant until at least 4 weeks after getting herpes zoster vaccine.
  • Someone with a minor acute illness, such as a cold, may be vaccinated. But anyone with a moderate or severe acute illness should usually wait until they recover before getting the vaccine. This includes anyone with a temperature of 101.3°F or higher.

    This information was taken from the Shingles Vaccine Information Statement dated 10/06/2009.

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    Very Common And Common Adverse Events

    Very common adverse events occur in 10% or more of vaccinees. Common adverse events occur in 1% to less than 10% of vaccinees.

    Injection site reactions are very commonly reported for both LZV and RZV. For LZV recipients the frequency is slightly higher in adults aged < 60 years. For all ages, the majority of these events were rated mild or moderate in intensity and lasted less than 2 days.

    Due to the adjuvant in RZV, which induces a high cellular immune response and helps address the natural age-related decline in immunity, RZV is more reactogenic than LZV.

    Injection site AEs are very commonly reported by recipients of RZV. Approximately 80% report injection-site pain and approximately 30% report redness at the site of injection.

    Systemic adverse events, primarily fatigue and myalgia are common in LZV recipients and very common in RZV recipients . For RZV, they include headache .

    Local and systemic reactions that were severe enough to interfere with normal activities have been more frequently reported following the receipt of RZV than LZV. However, these reactions have been temporary . Patient education on the short-term reactogenicity of the RZV is recommended prior to vaccine administration to promote adherence to the second dose.

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    How Is Shingles Treated

    What You Should Know About the Shingrix Vaccine for Shingles Prevention

    You can shorten and improve a shingles attack by quick treatment with antiviral drugs. Those include acyclovir, valcyclovir, or famcyclovir.

    Pain medicine can relieve some of the pain caused by shingles. Wet compresses, calamine lotion, and oatmeal baths may help relieve some of the itching.

    For most healthy people who receive treatment quickly, the pain should subside within three to five weeks and the blisters often leave no scars.

    If you think you may have shingles, call your health care provider as soon as possible to discuss treatment options.

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    When To See A Healthcare Provider

    For most people, the effects of Shingrix are mild and short-term. In very rare cases, Shingrix can cause more serious side effects.

    Seek urgent medical care if you experience signs of a severe allergic reaction a few minutes or hours after your second dose of Shingrix, such as:

    • Rapid heartbeat
    • Facial swelling
    • Swelling in the throat or mouth

    You should also let your healthcare provider know if your Shingrix side effects are severe or arent going away on their own.

    Skipping The Second Dose Of The Shingles Vaccine Might Mean You Have Less Protection Against This Painful Rash

    Medically reviewed in March 2021

    Shingles is a painful condition, and the effects of it can last for months or even years in some cases. Although there is no cure for shingles once you have it, there is a vaccine that prevents shingles in the first place.

    The Centers for Disease Control and Prevention recommends that healthy adults over the age of 50 get the shingles vaccine. This is true even if youve had shingles in the past, or if you were previously vaccinated with the older shingles vaccine.

    The shingles vaccine is administered in two separate dosesonce you receive the first dose, the second should be given 2 to 6 months later. After the second dose, the vaccine is more than 90 percent effective at preventing shingles, according to the CDC.

    Why the second dose matters The shingles vaccine is designed to be given as two doses, not as one. Despite the effectiveness of the vaccine, some people skip their second dose. Some simply forget to follow up and lose track of the appointment date. Others may skip the second dose due to costdepending on your insurance plan, you may be responsible for a co-pay or deductible fee, or you may need to pay for the second dose out of pocket.

    Getting the second dose gives you the full protection the vaccine offers. Below are some ways to make sure you get your second dose.

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    Outcome Definitions And Follow

    Our primary outcome was community HZ, defined by a claim in the OP or PB setting with an International Classification of Diseases, Tenth Revision, Clinical Modification diagnosis code for HZ in any position with a claim for HZ-specific antiviral , identified using NDCs, within 7 days of diagnosis. As a sensitivity analysis, we used this same clinical definition without requiring a prescription for antivirals. As secondary outcomes, we evaluated community ophthalmic zoster and PHN. We defined community OZ by a claim in the institutional OP or PB setting with an ICD-10 diagnosis code for OZ in any position , combined with a claim for a prescription for HZ-specific antivirals within 7 days of diagnosis. We defined PHN in the 90180 days after HZ onset using a modified version of the PHN algorithms from Klompas et al and Klein .

    Follow-up continued until occurrence of any of the following: a subsequent claim for a third dose of RZV death termination of Medicare Parts A/B or D coverage or enrollment into Part C admission to a nursing home, skilled nursing facility or hospice occurrence of either HZ, OZ, or PHN or end of the study period.

    Is It Possible To Get Shingles Twice

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    Most people who get shingles only experience it one time in their lives. However, it is possible to get shingles more than once . This is known as recurrent shingles. Getting vaccinated can help minimize the chance that this will happen.

    These are only a few of the many questions people may have about Shingrix. To learn more about the vaccine and shingles, individuals can consult a medical professional.

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    Study Population And Data

    This is a prospective cohort study with continuous accrual of people as they become age eligible for zoster vaccination. The study began on January 1, 2007, and continues through 2023. Eligibility is based on US dates of approval of the vaccine for people aged 60 years and older and for people 5059 years old . To ensure accurate ascertainment of vaccination status and baseline covariates, we restrict study entry to KPNC members with continuous membership since becoming age eligible for the zoster vaccine and at least 12 months of continuous membership before study entry. We exclude individuals who had an HZ diagnosis in the year before study entry. The cohort is updated annually to include newly age-eligible KPNC members.

    All members of the cohort start follow-up unvaccinated but are age eligible for vaccination. They contribute unvaccinated person-time while they remain unvaccinated if they receive the zoster vaccine, they then contribute vaccinated person-time. They contribute unvaccinated or vaccinated person-time until HZ diagnosis or follow-up is censored by disenrollment from KPNC, receipt of a second dose of zoster vaccine , death, or the end of available data .

    What Are The Main Differences Between Shingrix And Zostavax

    Shingrix is a recombinant, adjuvanted zoster vaccine that was first FDA-approved in 2017. It contains a certain protein called the varicella-zoster glycoprotein E antigen to produce an immune response in the body. Shingrix also contains an adjuvant, or added ingredient, to help boost the bodys immune response to the virus. The adjuvant suspension in Shingrix contains an extract from the Quillaja saponaria tree, known to modulate immune activity. Because Shingrix is an inactivated or non-live vaccine, it can be used in immunocompromised patients or those with a weakened immune system.

    Shingrix is administered as an injection into the muscle . It is given in two separate doses with a period of two to six months between the first and second doses. The second dose is necessary to ensure long-term effectiveness. Immunocompromised or immunodeficient individuals may require a shorter vaccine schedule and can get the booster one to two months after the first shot.

    Shingrix is currently the preferred shingles vaccine, according to the Centers for Disease Control and Prevention .

    Zostavax, approved in 2006, is a live, attenuated herpes zoster vaccine. In other words, Zostavax contains a weakened version of the actual virus to produce an immune response. For this reason, Zostavax is not recommended for those who are immunocompromised. Otherwise, the vaccine may cause a symptomatic infection, even weeks following vaccination.

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