Tuesday, September 26, 2023

Reaction To Second Shingles Shot

A New Shingles Vaccine

What are the side effects of the shingles shot?
  • U.S. News & World Report

If youre 50 or older, you’re advised to get immunized to protect yourself from shingles. If the new shingles vaccine made you feel worse than you expected, you’re not alone. Skin rash, joint pain, flu-like symptoms, headaches and fatigue are some complaints from patients who’ve had the recently approved Shingrix vaccine. Side effects can last two or three days, and the injection site in the upper arm can hurt. “Part of the problem is that health care providers may not have fully understood the instructions of administration,” said Talia Swartz, MD, PhD, assistant professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai. Providers can refer to the website of Shingrix manufacturer GSK for complete administration instructions for this relatively unfamiliar vaccine, Dr. Swartz suggested. “As providers are more comfortable with it, I believe the administration errors would be expected to be reduced,” she said.

– Talia Swartz, MD, PhD, Assistant Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai

Is Shingrix Good For A Lifetime

The Shingrix vaccine may need to be repeated once every five to seven years, but the immunity can last longer in some people. It is 90% effective for the first five years, and a booster shot is typically not needed. After five years, you may want to talk to your doctor or pharmacist about receiving another dose of the vaccine.

Rare Side Effects Of The Shingles Vaccine

In rare cases, a severe allergic reaction called anaphylaxis may occur. This can be a life-threatening emergency and requires immediate medical attention.

Symptoms of anaphylaxis after receiving the shingles vaccine include:

Typically, these side effects appear immediately or within a few minutes of vaccination your vaccination provider may be present. If you experience them after leaving the office, call 911.

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Allergic Reaction To Shingles Vaccination

There is a very small chance of a severe allergic reaction to the shingles vaccine, as there is with other vaccines.

Anaphylaxis is very serious and potentially life-threatening, but it can be treated. All healthcare staff that deliver vaccinations are trained in this. With prompt treatment, people fully recover from anaphylaxis.

Other Side Effects Of Shingrix

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Some side effects of zoster vaccine, inactivated may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

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Swelling Around The Injection Site

Swelling around the injection site is another common side effect of Shingrix. Like pain and redness, minor swelling can usually result from a localized immune system response, which isnt necessarily dangerous.

You can apply hydrocortisone cream on or around the injection site to reduce redness and swelling. However, if you experience severe swelling that doesnt go away, or the swelling accompanies other symptoms of an allergic reaction, seek medical attention right away.

Shingles Disease And How To Protect Against It

Shingles, or herpes zoster, is a painful skin rash that develops on one side of the face or body. It is caused by the varicella-zoster virus , the same virus that causes chickenpox. Anyone who has had chickenpox in the past can get shingles because VZV remains in the body after a person recovers from chickenpox. VZV can reactivate many years later, causing shingles.

Shingles is more common in older adults, people who have medical conditions that weaken the immune system, and people who take medications that suppress their immune systems. Getting vaccinated is the best way to prevent shingles.

Learn more about shingles.

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Shingles Vaccine Side Effects

Like all vaccines, the shingles vaccines can cause side effects, but theyre generally mild and do not last long.

Common side effects that occur in at least 1 in 10 people are:

  • redness, pain, swelling, itching and warmth at the injection site

If any side effects carry on for longer than a few days, speak to your GP or practice nurse.

Tell your GP if you develop a rash after having the shingles vaccination.

Weighing The Risks Vs Benefits

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The vaccine to prevent shingles will help you to avoid shingles symptoms, which in most cases are quite mild but may cause intense pain in some people.

Shingles symptoms come in two stages: the prodromal stage and the eruptive stage. In the first stage, your symptoms may include:

About three to five days later, you develop a prickly and painful pimple-like rash. These pimples turn into blisters during this eruptive stage, and your skin may be red and swollen. Shingles sores also can affect your mouth, which is another symptom the vaccine can prevent.

Shingles isn’t generally life-threatening. It can be, though, if your immune system is compromised. During an outbreak and after the rash clears up, some people may experience complications that require immediate medical attention.

Common ones include:

  • Postherpetic neuralgia : Damaged nerves cause lingering pain for three months or more.
  • Bacterial skin infections: When shingles blisters pop, bacteria can get in.
  • Eye damage: One branch of the trigeminal nerve goes to the eye. Damage there can lead to eye damage, which can be severe.

While you may experience side effects with the vaccine, the benefits outweigh the risks of shingles symptoms and complications in most people.

If you were vaccinated with Zostavaxa shingles vaccine that is no longer being givenask your healthcare provider about getting the Shingrix vaccine.

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What Are The Advantages Of Getting The Shingles Vaccine

The shingles vaccine reduces your risk of getting shingles. Shingles causes a painful rash that usually develops on one side of your body or face. Some people describe the pain as an intense burning or shooting sensation. The rash is often a single strip that wraps around one side of your body or is on one side of your face. It consists of blisters that normally crust over in seven to 10 days. The rash generally clears up within a month.

Some people with shingles also experience additional symptoms including fever, headache, chills or upset stomach.

For some people, the pain from the rash can last for months or even years after the rash goes away. This long-term pain is called postherpetic neuralgia , and it is the most common complication of shingles.

How Cdc Monitors Vaccine Safety

CDC and FDA monitor the safety of vaccines after they are approved or authorized. If a problem is found with a vaccine, CDC and FDA will inform health officials, health care providers, and the public.

CDC uses 3 systems to monitor vaccine safety:

  • The Vaccine Adverse Event Reporting System : an early warning system, co-managed by CDC and FDA, to monitor for potential vaccine safety problems. Anyone can report possible vaccine side effects to VAERS.
  • The Vaccine Safety Datalink : a collaboration between CDC and 9 health care organizations that conducts vaccine safety monitoring and research.
  • The Clinical Immunization Safety Assessment Project: a partnership between CDC and several medical research centers that provides expert consultation and conducts clinical research on vaccine-associated health risks.

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Does The Shingles Vaccine Contain Thimerosal

You may be concerned about additives to the shingles vaccine, like thimerosal.

Thimerosal is a preservative that contains mercury. Its added to some vaccines to prevent bacteria and other germs from growing in them. The shingles vaccine contains thimerosal.

The worry about thimerosal arose when early research linked it to autism. This connection has since been found to be untrue.

What Everyone Should Know About The Shingles Vaccine

Figure 1 from Herpes zoster following mRNA

Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia , the most common complication from shingles.

CDC recommends that adults 50 years and older get two doses of the shingles vaccine called Shingrix to prevent shingles and the complications from the disease. Adults 19 years and older who have weakened immune systems because of disease or therapy should also get two doses of Shingrix, as they have a higher risk of getting shingles and related complications.

Your doctor or pharmacist can give you Shingrix as a shot in your upper arm.

Shingrix provides strong protection against shingles and PHN. In adults 50 years and older who have healthy immune systems, Shingrix is more than 90% effective at preventing shingles and PHN. Immunity stays strong for at least the first 7 years after vaccination. In adults with weakened immune systems, studies show that Shingrix is 68%-91% effective in preventing shingles, depending on the condition that affects the immune system.

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What Questions Should I Ask My Healthcare Provider

Its normal to have questions before you get a vaccine. Some common questions you may want to discuss with your healthcare provider include:

  • When should I get the shingles vaccine?
  • What side effects should I expect?
  • How does the shingles vaccine work?
  • When should I schedule each dose of the shingles vaccine?
  • How effective is the shingles vaccine?
  • Is there any reason I shouldnt get the shingles vaccine?
  • What could happen if I dont get the shingles vaccine?

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When They Start How Long They Last

The shingles vaccine is given in a two-shot series. You may experience side effects after the first, second, or both shots. Most of the time, these symptoms are mild and occur immediately following vaccination. They typically only last for two or three days.

Side effects of the shingles vaccine are more common in younger people, and might interrupt your normal daily activities for a few days.

This may seem like a downside of the shingles vaccine, but remember that these symptoms are a result of the creation of a strong shingles defense within your body.

It is OK to take Tylenol or Advil after a shingles vaccine to relieve symptoms. Rest and plenty of fluids may help, too.

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What Vaccines Can Help Prevent Shingles

There is currently one vaccine available in the U.S. to prevent shingles. Shingrix was approved in 2017 and it is more than 90% effective in preventing shingles. With Shingrix, you get two shots between 2 and 6 months apart and protection lasts an estimated 4-5 years. Doctors recommend it for healthy people over 50 as well as those 19 years of age and older who are or will be immunodeficient or immunosuppressed due to disease or therapy..

An earlier vaccine called Zostavax was removed from the market in 2020. That vaccine used a weak form of the chickenpox virus to send your bodyâs immune system into action to fight the disease. Shingrix does not. If you received the Zostavax vaccine, it is recommended that you also receive Shingrix.

Shingrix Second Dose Side Effects

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The Shingrix vaccine is a two-dose series, which means that youll receive one dose of the vaccine, and then a second dose between 1 and 6 months later. In many cases, you may experience similar side effects from both your first and second shot.

However, in clinical trials , after receiving the second dose of Shingrix, headache and shivering were reported more often. So after your second dose of Shingrix, you may be at a higher risk of these side effects occurring.

However, most side effects from Shingrix only lasted between 2 and 3 days before easing. So if you do experience side effects, they are typically short term.

If you have questions or concerns about the possibility of side effects occurring from your second shot of Shingrix, talk with your doctor or pharmacist.

for Shingrix.

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Shingrix Vaccine Efficacy And Duration Of Protection

Among immunocompetent adults 50 years and older, the efficacy of two doses of Shingrix for the prevention of herpes zoster was high among all age groups. In a clinical trial of more than 30,000 participants, vaccine efficacy was 96.6% in adults aged 50 to 59 years, 97.4% in adults aged 60 to 69 years, and 91.3% in adults aged 70 years and older.

The efficacy of two doses of Shingrix for the prevention of postherpetic neuralgia was high: 91.2% in adults aged 50 years and older, and 88.8% in adults aged 70 years and older.

Vaccine efficacy was estimated among several immunocompromised groups:

  • 68.2% among adult autologous hematopoietic cell transplant recipients.
  • 87.2% in a post hoc efficacy analysis of adult patients with hematologic malignancies.
  • 90.5% in a post hoc efficacy analysis of adult patients with immune-mediated diseases who were not taking immunosuppressive medication.

In immunocompetent adults 70 years and older, vaccine efficacy remained high, at or above 84% in all 7 years after vaccination.

Side Effects Of Shingles Vaccine

The most common shingles shot side effects include pain and soreness at the injection site. Some people also notice a bit of redness, swelling or itching at the site of the shot. Other side effects of the shingles vaccine may include fatigue, muscle pain, headache, shivering, fever, stomach pain, or nausea. According to the CDC, side effects are more common in younger people than older people.

Most people can resume their regular activities immediately after vaccination. However, about 1 out of 6 people develop flu-like symptoms that last anywhere from 1 to 3 days.

Side effects can occur after the first, second, or both doses of Shingrix vaccine. If possible, it is a good idea to schedule vaccination the day before some downtime, so you can rest if you develop side effects.

If you develop flu-like symptoms after shingles vaccination, you can take ibuprofen or acetaminophen to control your fever and improve comfort. Those who develop flu-like symptoms after their first dose of vaccine may want to pre-medicate with ibuprofen or acetaminophen an hour or so before their second dose. Your healthcare provider can answer your questions about shingles vaccine side effects and pre-medication for vaccination.

Serious side effects are rare, but not impossible, after shingles vaccination. If you develop hives, swelling of the face or throat, difficulty breathing, a rapid heartbeat, or sudden dizziness or weakness, and seek medical care immediately.

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When To See A Healthcare Provider

For most people, the effects of Shingrix are mild and short-term. In very rare cases, Shingrix can cause more serious side effects.

Seek urgent medical care if you experience signs of a severe allergic reaction a few minutes or hours after your second dose of Shingrix, such as:

  • Rapid heartbeat
  • Facial swelling
  • Swelling in the throat or mouth

You should also let your healthcare provider know if your Shingrix side effects are severe or arent going away on their own.

Why Is Shingrix Administered In Two Doses

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Shingrix is typically given in two doses, usually as a shot to the upper arm.

A 2021 study found that adults over 65 were significantly less likely to develop either shingles or PHN after getting two doses of Shingrix than they were after one dose. Two doses of Shingrix also offered better protection against shingles complications to adults over 80 and immunocompromised adults.

Previously, Zostavax was offered to older and immunocompromised adults to prevent shingles, PHN, and other shingles-related health problems. Zostavax is a live vaccine, which means it contains a weakened version of the herpes zoster virus. Shingrix is a recombinant vaccine, meaning that it uses only a small piece of the virus.

In 2017, the Food and Drug Administration approved Shingrix for the prevention of shingles and related complications. Zostavax is no longer available in the U.S. People who have gotten Zostavax in the past should now get Shingrix.

Studies have shown that Zostavaxa one-dose vaccineis generally less effective than two doses of Shingrix in preventing shingles complications among older and immunocompromised adults. Shingrix currently offers the best chance of protection against shingles, PHN, and shingles-related hospitalization.

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What Is The Shingles Vaccine

The shingles vaccine can protect you against shingles and postherpetic neuralgia , which is the most common complication of shingles. Shingles is a painful rash caused by the varicella-zoster virus, the same virus that causes chickenpox. The rash usually develops on one side of your body or face. It starts with red bumps and then the bumps turn into fluid-filled blisters.

What Side Effects Can I Expect From The First Dose Of Shingrix

The Shingrix vaccine is a two-dose series, which means that youll receive one dose of the vaccine, and then a second dose between 1 and 6 months later. Mild side effects after getting your first dose of Shingrix are common. Examples of mild side effects that were commonly reported in

  • reaction at the injection site*

Though these side effects can occur after your Shingrix dose, not everyone receiving the vaccine will experience them. In addition, most side effects from Shingrix only lasted between 2 and 3 days before easing. So if you do experience side effects, they are typically short term.

If you have additional questions or concerns about what side effects to expect from your first dose of Shingrix, talk with your doctor or pharmacist.

* For more information about this side effect, see Side effect specifics above.

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What Does The Shingles Vaccine Do

The shingles vaccine can prevent shingles. Every year, about 1 million people in the United States get shingles. Anyone whos had chickenpox can get shingles. Thats because the varicella-zoster virus lives silently in your nervous system after you’ve had chickenpox. The virus can reactivate later in your life if your immune system is weakened. Your risk of getting shingles goes up as you get older. In the United States, 1 in 3 people will get shingles in their lifetime.

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